After drawing Leganes and Real Zaragoza, respectively, in the Copa Del Rey, LaLiga leaders Barcelona and second-placed Real Madrid face tough trips to Valencia and Real Valladolid, respectively, on matchday 21.
With both the sides level on point after 20 matchdays (43), Barcelona and Real Madrid will hope to return back home with all three points, with the season pushing forward towards the business end of the season.
Holders Barcelona defeated Granada 1-0 on Sunday at the Camp Nou to kick off their new era under manager Quique Setien, who was hired days after the sacking of Ernesto Valverde.
Real Madrid, on the other hand, edged Champions League hopefuls Sevilla 2-1 at the Bernabeu to extend their unbeaten run to 17 games in all competitions.
Los Blancos have lost just one game in the league — a 0-1 defeat at Mallorca in October– so far, thanks largely to their backline and the remarkable form of shot-stopper Thibaut Courtois.
Courtois, after a slow start to the season, has regained his top form and will be hoping to register his 13th clean sheet, in all competitions, this season at the Estadio Jose Zorrilla on Sunday.
Barca, meanwhile, despite bagging plenty of goals have been far from convincing at the back.
After enjoying a rare clean sheet last weekend against Granada, Barca will look for a similar outcome when they travel to face Valencia, later today, at the Mestalla.
On Friday, Osasuna kicked off matchday 21 after defeating Levante 2-0 at El Sadar. A goal each in the second half from Ruben Garcia and Inigo Perez saw them end a five-game winless run in the league.
Other LaLiga Fixures:
Espanyol vs Athletic Bilbao, Saturday
Alaves vs Villareal, Saturday
Sevilla vs Granada, Sunday
Atletico Madrid vs Granada, Sunday
Celta Vigo vs Eibar, Sunday
Granada vs Real Betis, Sunday
Real Sociedad vs RCD Mallorca, Sunday