Defending Champions Manchester City will welcome Crystal Palace before Liverpool and Manchester United end matchday 23 of the Premier League at Anfield on Sunday.
Liverpool, who are top of the table, are still unbeaten after 22 game weeks with Manchester United, their opponents on Sunday, being the only team to snatch points from the table-toppers.
United and Liverpool shared spoils when these two sides met back at Old Trafford in October. Marcus Rashford gave United a deserved lead in the first half before Adam Lallana equalised late in the second half, in front of the Stretford End.
The Reds currently sit at the top, 14 points ahead of second-placed Manchester City, who entertain Crystal Palace, having defeated them 2-0 in the reverse fixture, also in October.
Tottenham Hotspur kicks off matchday 23, hoping to end a run of 3 games without a win in the Premier League, with a trip to Watford on Saturday.
But Mourinho’s men will be boosted by their 2-1 success over Middlesborough in FA Cup third-round replay.
Spurs, however, will be without striker Harry Kane, who had torn his hamstring against Liverpool, last weekend.
Leicester City, third with 45 points so far, also hit the road on Sunday, this time at Burnley, following last week’s disappointing 1-2 defeat at home to Southampton.
The Foxes have experienced a sudden dip in form, but a place in the next year’s Champions League is still within the site of the 2015 champions.
Chelsea, fourth in the table, also faces a tough trip away at Newcastle United while Arsenal welcome high-flyers Sheffield United, who are above their Saturday’s opponents.
Other Premier League fixtures:
Brighton vs Aston Villa, AmEx Stadium, Saturday
West Ham vs Everton, London Stadium, Saturday
Norwich vs Bournemouth, Carrow Road, Saturday
Southampton vs Wolverhampton Wanderers, St Mary’s Stadium, Saturday